Notes

Bartonella quintana

0

Ricketsia typhi – Ricketsia tsutsugamushi

0

Ricketsia prowazeki

0

Ricketsia akari

0

Ricketsia ricketsii

0

Mycobacterium leprae

Mycobacterium avium complex

Mycobacterium tuberculosis

Acid-fast bacilli, Non-motile, 40% mycolic acid, aerobe, Cat ⨁ Virulence Mycolic acid ⇒ Mycosides Cord factor→ TNF-α ⇒ Cachectia Sulfatid → Inhibit phagolysosome Wax D → Immunogenic Clinic Primary → Lower lobe Asymptomatic → Ghon complex Overt disease in ↓ immune Secondary Pulmonary → Upper lobe cavity Cervical lymph...

Ureaplasma ureliticum

No cell wall, Pleomorphic Virulence Urease → (Urea → NH3 + CO2) ⇒ Grows in urine Requires cholesterol and urea to grow Clinic → Non-gonococcal urethritis Diagnosis → Very tiny colonies (T-strain mycoplasma) Treatment → Tetracycline, Erythromycin

Mycoplasma pneumoniae

No cell wall, Pleomorphic, Motile, Facultative anaerobe Virulence Protein P1 → Adheres to respiratory epithelium Requires cholesterol for membrane No toxin Epidemiology → Disease in children, adolescents, young adults Clinic Tracheobronchitis Walking Pneumonia → CXR worse that patient, fever + dry cough Diagnosis Cold agglutinin (IgM) ⇒ Hemolysis until...

Chlamydia pneumoniae

g⊖ very small, Obligate intracellular, Muramic acid ⊖, Cell wall ⊖ Epidemiology → Human reservoir → Respiratory route Virulence → Resistant to lysosome, ATM parasite Life cycle → Elementary body, Reticulate body Clinic → Strain TWAR → Atypical pneumonia Diagnosis Serology, Intracytoplasmic inclusion → NOT stained with iodine C. trachomatis...

Chlamydia psittaci

g⊖ very small, Obligate intracellular, Muramic acid ⊖, Cell wall ⊖ Epidemiology → Birds, Pet parrot → Dried feces inhaled Virulence → Resistant to lysosome, ATM parasite → ATP/ADP translocator Life cycle → Elementary body, Reticulate body Clinic → Psittacosis → Atypical pneumonia Diagnosis Serology, Intracytoplasmic inclusion → NOT stained...