Atypical

Ureaplasma ureliticum

No cell wall, Pleomorphic Virulence Urease → (Urea → NH3 + CO2) ⇒ Grows in urine Requires cholesterol and urea to grow Clinic → Non-gonococcal urethritis Diagnosis → Very tiny colonies (T-strain mycoplasma) Treatment → Tetracycline, Erythromycin

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Mycoplasma pneumoniae

No cell wall, Pleomorphic, Motile, Facultative anaerobe Virulence Protein P1 → Adheres to respiratory epithelium Requires cholesterol for membrane No toxin Epidemiology → Disease in children, adolescents, young adults Clinic Tracheobronchitis Walking Pneumonia → CXR worse that patient, fever + dry cough Diagnosis Cold agglutinin (IgM) ⇒ Hemolysis until...

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Chlamydia pneumoniae

g⊖ very small, Obligate intracellular, Muramic acid ⊖, Cell wall ⊖ Epidemiology → Human reservoir → Respiratory route Virulence → Resistant to lysosome, ATM parasite Life cycle → Elementary body, Reticulate body Clinic → Strain TWAR → Atypical pneumonia Diagnosis Serology, Intracytoplasmic inclusion → NOT stained with iodine C. trachomatis...

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Chlamydia psittaci

g⊖ very small, Obligate intracellular, Muramic acid ⊖, Cell wall ⊖ Epidemiology → Birds, Pet parrot → Dried feces inhaled Virulence → Resistant to lysosome, ATM parasite → ATP/ADP translocator Life cycle → Elementary body, Reticulate body Clinic → Psittacosis → Atypical pneumonia Diagnosis Serology, Intracytoplasmic inclusion → NOT stained...

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Chlamydia trachomatis

g⊖ very small, Peptidoglycan ⊖, Muramic acid ⊖, Obligate intracellular Life cycle Elementary body → Small, infective, transmits by contact Reticulate body → Large, intracellular, ATP parasite Clinic A-C → Trachoma → Chronic conjunctivitis → Keratitis ⇒ Blindness (Africa) D-K Infants → Inclusion conjunctivitis, Pneumonia (eosinophilia, staccato cough, 1-3 m...

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